box-shadow

значения свойства:

none
shodow-x
shodow-y
blur
spread
color
inset

css/style.css

* {
margin: 0;
padding: 0;
}
.main {
height: 600px;
width: 900px;
position: absolute;
top: 50%;
left: 50%;
margin-top: -300px;
margin-left: -450px;
}
.wrapper {
width: 25%;
height: 100%;
float: left;
}
#div1, #div2, #div3, #div4 {
height: 150px;
width: 150px;
float: left;
position: relative;
top: 50%;
left: 50%;
margin-top: -75px;
margin-left: -75px;
background-color: #3BA9DE;
}
#div1 {
box-shadow: 15px 15px #7092BE;
}
#div4 {
box-shadow: 25px 25px 5px 10px #7092BE inset;
}

* {
 margin: 0;
 padding: 0;
}

.main {
 height: 600px;
 width: 900px;
 position: absolute;
 top: 50%;
 left: 50%;
 margin-top: -300px;
 margin-left: -450px;
}

.wrapper {
 width: 25%;
 height: 100%;
 float: left;
}

#div1, #div2, #div3, #div4 {
 height: 150px;
 width: 150px;
 float: left;
 position: relative;
 top: 50%;
 left: 50%;
 margin-top: -75px;
 margin-left: -75px;
 background-color: #3BA9DE;
} 

#div1 {
 box-shadow: 15px 15px #7092BE;
}

#div4 {
 box-shadow: 25px 25px 5px 10px #7092BE inset;
}

index.html

<!DOCTYPE html>
<html>
<head>
<meta charset="utf-8" />
<title>New Page</title>
<link href="css/style.css" rel="stylesheet" />
<script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.7.2/jquery.min.js"></script>
</head>
<body>
<div class="main">
<div class="wrapper">
<div id="div1"></div>
</div>
<div class="wrapper">
<div id="div2"></div>
</div>
<div class="wrapper">
<div id="div3"></div>
</div>
<div class="wrapper">
<div id="div4"></div>
</div>
</div>
<script>
/*JavaScript*/
document.getElementById("div2").style.boxShadow = "25px 25px 5px #7092BE";
/*jQuery*/
$(document).ready(function () {
$("#div3").css({ "box-shadow": "25px 25px 5px 10px #7092BE" });
});
</script>
</body>
</html>

<!DOCTYPE html>
<html>
<head>
<meta charset="utf-8" />
<title>New Page</title>
<link href="css/style.css" rel="stylesheet" />
<script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.7.2/jquery.min.js"></script>
</head>
<body>
<div class="main">
<div class="wrapper">
<div id="div1"></div>
</div>
<div class="wrapper">
<div id="div2"></div>
</div>
<div class="wrapper">
<div id="div3"></div>
</div>
<div class="wrapper">
<div id="div4"></div>
</div>
</div>
<script>
/*JavaScript*/
document.getElementById("div2").style.boxShadow = "25px 25px 5px #7092BE";
/*jQuery*/
$(document).ready(function () {
$("#div3").css({ "box-shadow": "25px 25px 5px 10px #7092BE" });
});
</script>
</body>
</html>